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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VI
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA
Year:
1962
Bibliographic source:
Am Ind Hyg Ass J 23, 95-107, 1962

Materials and methods

Principles of method if other than guideline:
Groups of 6 male or female rats were exposed to concentrated vapour of bis(2-ethylhexyl) hydrogen phosphate for up to 8 hours.
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) hydrogen phosphate
EC Number:
206-056-4
EC Name:
Bis(2-ethylhexyl) hydrogen phosphate
Cas Number:
298-07-7
Molecular formula:
C16H35O4P
IUPAC Name:
bis(2-ethylhexyl) hydrogen phosphate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
no
Concentrations:
Rats were exposed to concentrated vapour of the test substance - but no analytical data were presented in the publication.
A saturated chamber atmosphere has a concentration of 1300 mg/m³ according the BUA report no 172.
No. of animals per sex per dose:
6 male or six female animals/exposure period
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 1 300 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
8 h

Any other information on results incl. tables

After an exposure of 8 hours in a concentrated vapours atmosphere no animals died within 14 days.

Applicant's summary and conclusion

Executive summary:

No animals died within 14 days after an exposure of 8 hours in a concentrated test atmosphere.