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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1943
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Sensory response to certain industrial solvent vapours
Author:
Nelson K.W. et al.
Year:
1943
Bibliographic source:
J. Ind. Hyg. and Toxicol. 25, 282-285, 1943

Materials and methods

Endpoint addressed:
skin irritation / corrosion
eye irritation
respiratory irritation
Principles of method if other than guideline:
Sensory limit tests in humans
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Method

Exposure assessment:
not specified

Results and discussion

Results:
Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapor irritated majority of subjects)

Applicant's summary and conclusion

Conclusions:
Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapour irritated majority of subjects)
Executive summary:

Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapour irritated majority of subjects)