Registration Dossier
Registration Dossier
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EC number: 217-316-1 | CAS number: 1809-19-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1943
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensory response to certain industrial solvent vapours
- Author:
- Nelson K.W. et al.
- Year:
- 1 943
- Bibliographic source:
- J. Ind. Hyg. and Toxicol. 25, 282-285, 1943
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
- eye irritation
- respiratory irritation
- Principles of method if other than guideline:
- Sensory limit tests in humans
- GLP compliance:
- no
Test material
- Reference substance name:
- Source Chemical 09
- IUPAC Name:
- Source Chemical 09
- Test material form:
- liquid
Constituent 1
Method
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapor irritated majority of subjects)
Applicant's summary and conclusion
- Conclusions:
- Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapour irritated majority of subjects) - Executive summary:
Sensory irritation/Irritation:
< 25 ppm = 75 mg/m3: highest concentration which majority of subjects estimated satisfactory for 8 hour exposure
50 ppm = 150 mg/m3: eye irritation (vapour irritated majority of subjects)
25 ppm: nose irritation (vapour irritated majority of subjects)
25 ppm: throat irritation (vapour irritated majority of subjects)
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