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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 11 July to 6 August, 1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
Deviations:
no
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
1000, 3000 mg/kg bw
No. of animals per sex per dose:
10 animals per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Mortality:
One rat during the first day of observation period after administration of the highest dose.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified according to CLP Regulation (EC no. 1272/2008)
Conclusions:
LD50 (oral, rat) > 3000 mg/kg bw
Executive summary:

The acute oral toxicity of the test item was evaluated in an experimental study similar to the OECD Guideline 420, according to the fixed dose procedure. The test item was administered to groups of 10 male/female Wistar rats by oral gavage, at doses of 1000 or 3000 mg/kg bw. One rat from the low-dose group died on the first day of the observation period; no further mortality occurred in either group. The acute oral LD50 is, therefore, considered to be greater than 3000 mg/kg bw.