Dibutyl phosphonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 11 July to 6 August, 1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

no

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dibutyl phosphonate

EC Number:

217-316-1

EC Name:

Dibutyl phosphonate

Cas Number:

1809-19-4

Molecular formula:

C8H19O3P

IUPAC Name:

dibutyl phosphonate

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

1000, 3000 mg/kg bw

No. of animals per sex per dose:

10 animals per dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 000 mg/kg bw

Based on:

test mat.

Mortality:

One rat during the first day of observation period after administration of the highest dose.

Clinical signs:

other:

Applicant's summary and conclusion

Interpretation of results:

other: Not classified according to CLP Regulation (EC no. 1272/2008)

Conclusions:

LD50 (oral, rat) > 3000 mg/kg bw

Executive summary:

The acute oral toxicity of the test item was evaluated in an experimental study similar to the OECD Guideline 420, according to the fixed dose procedure. The test item was administered to groups of 10 male/female Wistar rats by oral gavage, at doses of 1000 or 3000 mg/kg bw. One rat from the low-dose group died on the first day of the observation period; no further mortality occurred in either group. The acute oral LD₅₀ is, therefore, considered to be greater than 3000 mg/kg bw.