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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From June 20 to July 19, 1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
Deviations:
no
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Housing: 40 L exposure chamber

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
- Air flow: 6.84 L/min
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 1 h
Concentrations:
Nominal 22.53 mg/L
No. of animals per sex per dose:
10 laboratoty test rats
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 22.53 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
1 h
Mortality:
No mortality occurred
Clinical signs:
other:

Applicant's summary and conclusion

Interpretation of results:
other: Not classified according CLP Regulation (EC no. 1272/2008)
Conclusions:
LC0 (inhalation, rat, 1h) = 22.53 mg/L
Executive summary:

The acute inhalation toxicity of the test item was evaluated in an experimental study performed in an equivalent manner to the OECD Guideline 433, Acute Inhalation Toxicity Fixed Concentration Procedure. 10 rats were exposed to the test item via a whole body air chamber with an air flow of 6.84L/minute for approximately one hour, in a limit test with a nominal concentration equivalent to 22.53 mg/L.

No mortality occurred during the study period. Mild erythema on ears, inactivity, salivation, nasal discharge during exposure was observed. The LC50 is therefore greater than 22.53 mg/L (nominal), and the LC0 is equal to 22.53 mg/L (nominal).