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EC number: 217-316-1 | CAS number: 1809-19-4
The acute dermal toxicity of the test item was evaluated in an experimental study according to a method equivalent to the OECD Guideline 434, following the fixed dose procedure. 5000 mg/kg bw of test item was applied to the clipped, abraded skin of 12 male New Zealand albino rabbits for 72 hours, then surviving animals were observed for 14 days. The abrasion was performed 2-3 cm over the area of exposure, equivalent to approximately 10 % coverage; sufficiently deep to penetrate the stratum corneum, but not deep enough to disturb the derma. A subsequent group of rabbits was exposed in the same way to 4000 mg/kg bw.
Clinical signs included oedema, erythema and mortality in 6 out of 12 animals from the high-dose group. At the dose level of 4000 mg/kg bw, the test item produced oedema, erythema and eschar, but no mortality. The LD50 is therefore considered to be 5000 mg/kg bw, and the LD0 is considered to be 4000 mg/kg bw.
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