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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Methyl lactate, as all lactate esters, is rapidly hydrolyzed in-vivo into lactic acid and the associated alcohol (methanol; see 7.9.3.001).

Lactic acid is a ubiquitous and essential biological molecule, in humans and other mammals, but also in most if not all vertebrate and invertebrate animals, as well as in many micro-organisms. As such the biokinetics, metabolism and distribution of lactic acid have to be considered in the context of its normal biochemistry; exogenous lactic acid will be indistinguishable from endogenous lactic acid and will follow the same biochemical pathways as endogenous lactic acid, at least up to a certain systemic level.

The biochemistry of lactic acid has been reviewed and summarized in Sterenborg, 2007 (see the lactic acid registration dossier).

Methanol is an alcohol that is metabolized by the normal alcohol metabolism pathways.