Registration Dossier
Registration Dossier
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EC number: 203-236-4 | CAS number: 104-78-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2e
Data source
Reference
- Reference Type:
- publication
- Title:
- RANGE-FINDING TOXICITY DATA : LIST VI
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC and Striegel JA
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation risk-test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-aminopropyldiethylamine
- EC Number:
- 203-236-4
- EC Name:
- 3-aminopropyldiethylamine
- Cas Number:
- 104-78-9
- Molecular formula:
- C7H18N2
- IUPAC Name:
- (3-aminopropyl)diethylamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
by passing 2.5L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 mL of the test chemical contained in a gas-washing bottle. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- saturated vapor
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Effect level:
- other: atmosphere saturated with vapours
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality
- Mortality:
- No mortality at saturated vapor for 4 hours
- Clinical signs:
- other: No data
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality at saturated vapor for 4 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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