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Ecotoxicological information

Toxicity to terrestrial plants

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Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the toxicity to terrestrial plants.

Key value for chemical safety assessment

Additional information

No experimental data evaluating the toxicity of Glycerides, C8-C10, mono- and di- (CAS No. 85536-07-8) to terrestrial plants are available.


The test substance is characterized by a log Kow > 3 indicating potential for adsorption to soil particles. Tests with soil-dwelling organisms that feed on soil particles are therefore most relevant for the evaluation of soil toxicity of Glycerides, C8-C10, mono- and di-. Due to the adsorption potential of this substance, it is not expected to be found in the soil pore water, and uptake by plants is therefore unlikely. Moreover, the Guidance on information requirements and chemical safety assessment, Chapter R7.c states that earthworm testing allows potential uptake via surface contact, soil particle ingestion and pore water, while plant exposure will be largely via pore water (ECHA, 2012). Therefore, earthworm was chosen as the most suitable organism to assess the terrestrial toxicity of this substance. The Guidance on information requirements and chemical safety assessment Chapter R.7c, (ECHA, 2012) states that in the absence of a clear indication of selective toxicity, an invertebrate (earthworm or collembolan) test is preferred.


Earthworm tests conducted on two analogue category members are used as read-across (in accordance with Regulation (EC) No. 1907.2006, Annex XI, 1.5). Both studies were performed according to OECD 207, showing no effects on survival or biomass of Eisenia fetida after 14 days, leading to NOEC values (14 d) ≥ 1000 mg/kg dw (limit tests) (Muckle, 2012; Moser, 2012).


Glycerides, C8-C10, mono- and di- is readily biodegradable. Therefore, rapid and ultimate degradation in the environment, including soil, can be expected. Chronic exposure of terrestrial organisms is thus very unlikely. Furthermore, this substance did not show acute toxicity to fish and aquatic invertebrates up to the limit of its water solubility (46 mg/L).Low toxicity was reported for algae species, leading to a NOELR = 20.7 mg/L (loading rate), corresponding to a mean measured concentration of 1.19 mg/L. Nevertheless, physical effects due to interference or adsorption of the substance to algae cells cannot be excluded.These results indicate no or only low toxicity to terrestrial organisms is expected. Due to the metabolization via enzymatic hydrolysis of the Glycerides category members, a relevant uptake and bioaccumulation in biota is not expected. Enzymatic breakdown will initially lead to the free fatty acid and glycerol. Glycerides are naturally stored by organisms as long-term energy reserves. Especially in periods in which the energy demand is high (reproduction, migration, etc.), glycerides are mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species, resulting in the release of acetyl CoA and NADH (throughβ-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. Please refer to IUCLID Section 5.3.1 for a detailed overview on bioaccumulation of the Glycerides category members.

Based on the available information, the chemical safety assessment according to Regulation (EC) No. 1907/2006, Annex I, does not indicate the need to conduct further tests on terrestrial plants.