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Registration Dossier
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EC number: 226-106-9 | CAS number: 5280-78-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Fed. Reg. (17 Sept 1964, § 191.11) = Draize test
- Deviations:
- not applicable
- Remarks:
- test method not reported in detail
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N'-(2-chloro-1,4-phenylene)bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide]
- EC Number:
- 226-106-9
- EC Name:
- N,N'-(2-chloro-1,4-phenylene)bis[4-[(2,5-dichlorophenyl)azo]-3-hydroxynaphthalene-2-carboxamide]
- Cas Number:
- 5280-78-4
- Molecular formula:
- C40H23Cl5N6O4
- IUPAC Name:
- N,N'-(2-chloro-1,4-phenylene)bis{4-[(2,5-dichlorophenyl)diazenyl]-3-hydroxy-2-naphthamide}
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Physical state: powder
- Analytical purity: no data
Constituent 1
- Specific details on test material used for the study:
- - Physical state: powder
- Analytical purity: no data
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: polyethylene glycol
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
mixed with the powdered material to a paste - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM: OECD Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.16
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: slight erythema (score 1) was observed in 2 animals only at the 72 hr reading
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.08
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: slight edema (score 1) was observed in 1 animal only at the 72 hr reading
Applicant's summary and conclusion
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