Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
only basic data given; test substance purity not specified; observation time not given
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl stearate
EC Number:
203-934-9
EC Name:
Isopropyl stearate
Cas Number:
112-10-7
Molecular formula:
C21H42O2
IUPAC Name:
isopropyl stearate
Details on test material:
- Name of test material (as cited in study report): stearate d'isopropyle
- Physical state: no data
- Analytical purity: no data
- Lot/batch No.: 1511

Test animals

Species:
mouse
Strain:
NMRI
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 20 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses:
5 mL/kg bw
No. of animals per sex per dose:
5 females
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 4 300 mg/kg bw
Based on:
test mat.
Remarks:
converted from 5 mL/kg bw based on a density of 0.87 g/mL, see IUCLID Section "Physical and chemical properties, Density"
Mortality:
No mortality occurred during the study period.
Clinical signs:
No clinical signs occurred during the study period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified
DSD: not classified