Registration Dossier
Registration Dossier
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EC number: 203-288-8 | CAS number: 105-34-0
Endpoint summary
Administrative data
Description of key information
No studies on the acute toxicity of methyl cyanoacetate are available.
Nevertheless, according to a MSDS by Sigma-Aldrich (2008), the LD50 for acute oral toxicity of methyl cyanoacetate in rat is 3062 mg/kg bw. .
For the dermal route, an LD50 > 2000 mg/kg bw for rabbit is reported by Sigma-Aldrich in the MSDS mentioned above.
No data on acute inhalation are available.
Key value for chemical safety assessment
Additional information
According to a MSDS by Sigma-Aldrich (2008), the LD50 for acute oral toxicity of methyl cyanoacetate in rat is 3062 mg/kg bw. Unpublished data from Eastman Kodak Co. are cited in Patty's Toxicology (5th Edition, 2001); according to these data, the acute oral LD50 value for Guinea pig is in the range of 400 to 800 mg/kg bw. Since the data provided by Sigma-Aldrich refer to the rat as the most relevant, recommended species to be used for acute oral toxicity testing, the LD50 of 3062 mg/kg bw was retained for assessment of the oral route of exposure.
For the dermal route, an LD50 > 2000 mg/kg bw for rabbit is reported by Sigma-Aldrich in the MSDS mentioned above. Furthermore, an LDLo of 400 mg/kg bw for acute dermal toxicity is cited for Guinea pig, as secondary quotation in RTECS. Thus, the LD50 provided by Sigma-Aldrich was considered for assessment.
No data on acute inhalation are available.
Justification for classification or non-classification
Only few data are available referring to the acute toxicity of Methyl cyanoacetate. For the oral route, the LD50 for rat was 3062 mg/kg bw; for the dermal route, the LD50 for rabbit was > 2000 mg/kg bw. Thus, no classification for both routes according to the EU Directive 67/548 /EEC, and no classification according to the CLP Regulation 1272/2008/EC, is expected.
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