Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Manufacturer/producer data without proof.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
Buehler test

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl cyanoacetate
EC Number:
203-288-8
EC Name:
Methyl cyanoacetate
Cas Number:
105-34-0
Molecular formula:
C4H5NO2
IUPAC Name:
methyl 2-cyanoacetate
Details on test material:
no details on test material as used in the original study are available.

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
no data
Challengeopen allclose all
Route:
other: no data
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
no data

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: no details on results provided.
Clinical observations:
The test item was not sensitizating.
Remarks on result:
other: Reading: other: no details on results provided.. Clinical observations: The test item was not sensitizating..

Any other information on results incl. tables

No further details of the study conditions were available.

Applicant's summary and conclusion