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EC number: 272-940-1 | CAS number: 68921-45-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 August 2012 to 20 November 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with OECD, EU and US EPA test guidelines in coompliance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 0.706 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.9 - <= 7
- Details on results:
- Preliminary test
The content of test substance dissolved in the water sample after one centrifugation step was 1.99 mg/l.
Main study
The coefficient of variation (CV) (n = 10) was ≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30%. Based on this, the water solubility of the test substance is given as the mean value of these measurements.
The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
No test substance was detected in the samples from the blank column, except for one sample in which a concentration of 0.000113 mg/l was measured. - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test substance at 20°C was 0.706 mg/l. - Executive summary:
The aim of the study is to determine the following physico-chemical property for Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene: Water solubility, using the following guidelines:
European Community (EC), EC no. 440/2008, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.6: “Water Solubility”, Official Journal of the European Union no. L142, May 31, 2008.
Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals no. 105: "Water Solubility", July 27, 1995.
United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7840: "Water Solubility: Column Elution Method; Shake Flask Method", March 1998.
The column elution method was applied for the determination of the water solubility of Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene.
The water solubility of the test substance at 20°C was 0.706 mg/l.
The pH of the aqueous samples was 6.9 – 7.0.
Reference
Main Study – water solubility of test substance
Flow rate
[ml/h] |
Sample no. |
Concentration analysed |
pH |
||||
Individual [mg/l] |
Mean1[mg/l] |
CV [%] |
Mean2[mg/l] |
MD [%] |
|||
24 |
1 |
0.4263 |
0.677 |
19 |
0.706 |
8.2 |
7.0 |
|
2 |
0.4503 |
|
|
|
|
|
|
3 |
0.4713 |
|
|
|
|
|
|
4 |
0.4943 |
|
|
|
|
|
|
5 |
0.609 |
|
|
|
|
|
|
6 |
0.569 |
|
|
|
|
|
|
7 |
>14 |
|
|
|
|
|
|
8 |
0.846 |
|
|
|
|
|
|
9 |
0.571 |
|
|
|
|
|
|
10 |
0.789 |
|
|
|
|
|
12 |
1 |
0.726 |
0.734 |
4.8 |
|
|
6.9 |
|
2 |
0.815 |
|
|
|
|
|
|
3 |
0.710 |
|
|
|
|
|
|
4 |
0.778 |
|
|
|
|
|
|
5 |
0.736 |
|
|
|
|
|
|
6 |
0.725 |
|
|
|
|
|
|
7 |
0.724 |
|
|
|
|
|
|
8 |
0.710 |
|
|
|
|
|
|
9 |
0.714 |
|
|
|
|
|
|
10 |
0.705 |
|
|
|
|
|
1Mean of the concentrations obtained at one flow rate.
2Mean of the concentrations obtained at both flow rates
3This value was not used for calculation of the mean because the system had not reached equilibrium yet
4This value was not used for calculation of the mean because this value was obtained by extrapolation of the calibration curve.
Description of key information
Key value determined using EU Method A6, OECD guideline 105 and US EPA test guideline OPPTS 830.7840.
Key value for chemical safety assessment
- Water solubility:
- 0.706 mg/L
- at the temperature of:
- 20 °C
Additional information
The column elution method was applied for the determination of the water solubility of Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene.
The water solubility of the test substance at 20°C was 0.706 mg/l.
The pH of the aqueous samples was 6.9 – 7.0.
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