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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

96 h LC50 (Pimephales promelas) = 2.27 mg/L (C.I. 1.86 - 2.83 mg/L), NOEC = 0.958 mg/L, OECD 203 (Boeri, 2004)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
2.27 mg/L

Additional information

In the key study, the acute toxicity of the test material to the fathead minnow (Pimephales promelas) was determined in a 96 hour semi-static test conducted in accordance with the OECD Guideline for Testing of Chemicals No. 203 under GLP conditions.

The nominal concentrations tested were 0.65, 1.1, 1.8, 3.0 and 5.0 mg/L, along with a parallel control and DMF solvent control. The analytically determined test material concentrations in the test media varied in the range from 87 to 95 % of the nominal value.

Exposure of fathead minnows to the test material resulted in a 96-hour median lethal concentration (LC50) of 2.27 mg/L, with a 95 % confidence interval of 1.86 to 2.83 mg/L. The 96 hour no observed effect concentration (NOEC) was 0.958 mg/L (this concentration allowed 90 % survival with no sub-lethal effects). After 96 hours of exposure, there was 100 % survival in the control and solvent control.