Registration Dossier

Administrative data

Description of key information

MBB is considered as non-irritant and non corrosive on skin (in vitro experiments) and  non-irritant on eyes (in vitro experiments) when applied diluted. MBB was considered as irritant to eye when applided at neat concentration for 10 seconds on isolated chicken eye (ICE).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

MBB was considered non corrosive in in-vitro skin corrosion (Transcutaneous Electrical Resistance) assay. The mean TER value recorded for MBB after a 24 h contact period was 14.0 kΩ (above the cut off value of 5 kΩ). 

This in-vitro skin corrosion test is classified as acceptable, and satisfies the guideline requirements of the OECD 430 method.

MBB was classified as non-irritant to the skin when applied at 1.83 and 6.1% w/v in sterile water and neat (% MTT viability >50%) according to the prediction model based on MTT viability analysis.

This in-vitro acute skin irritation test is classified as acceptable, and satisfies the guideline requirements of the OECD 431 method.

MBB was classified as an irritant to the isolated chicken eye (ICE in-vitro study) when applied neat for 10 sec. Other in vitro studies on MBB and MBB sulfate (in vitro) for eye irritation on diluted test items showed no irritant effect.


Effects on eye irritation: irritating

Justification for classification or non-classification

The CLP classification was based on the effect of the substance when applied pure on skin and eyes. The substance was therefore considered as non classified for the skin irritation and classified categorie 2 for the eye irritation : causes serious eye irritation (H319).