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EC number: 204-485-1 | CAS number: 121-60-8
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Estimation of the half-life value of test chemical in water. The estimations were done using the Fugacity Model of the Estimation Programs Interface (EPI) Suite v.4.1 program developed by the U. S. Environmental Protection Agency's. The Fugacity Model in EPI suite is a level III multimedia fate model and predicts the half-life and partitioning of an organic compound in an evaluative environment mainly between four main compartments; that is, air, water, sediment and soil.
- GLP compliance:
- no
- Radiolabelling:
- no
- Oxygen conditions:
- other: estimation
- Inoculum or test system:
- not specified
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Compartment:
- water
- % Recovery:
- 33.4
- Remarks on result:
- other: Other details not known
- Key result
- % Degr.:
- 50
- Parameter:
- other: Half-life in water
- Sampling time:
- 37.5 d
- Remarks on result:
- other: Other details not known
- Key result
- Compartment:
- water
- DT50:
- 37.5 d
- Type:
- other: estimated data
- Temp.:
- 25 °C
- Remarks on result:
- other: Other details not known
- Transformation products:
- not specified
- Evaporation of parent compound:
- not specified
- Volatile metabolites:
- not specified
- Residues:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Estimated half life of test chemical in water was 37.5 days (900 h).
- Executive summary:
Estimation Programs Interface prediction model was run to predict the half-life in water for the test chemical. If released in to the environment, 33.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low.
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Estimation of the half-life value of test chemical in sediment. The estimations were done using the Fugacity Model of the Estimation Programs Interface (EPI) Suite v.4.1 program developed by the U. S. Environmental Protection Agency's. The Fugacity Model in EPI suite is a level III multimedia fate model and predicts the half-life and partitioning of an organic compound in an evaluative environment mainly between four main compartments; that is, air, water, sediment and soil.
- GLP compliance:
- no
- Radiolabelling:
- no
- Oxygen conditions:
- other: estimation
- Inoculum or test system:
- not specified
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Compartment:
- sediment
- % Recovery:
- 0.083
- Remarks on result:
- other: Other details not known
- Key result
- % Degr.:
- 50
- Parameter:
- other: Half-life in sediment
- Sampling time:
- 337.5 d
- Remarks on result:
- other: Other details not known
- Key result
- Compartment:
- sediment
- DT50:
- 337.5 d
- Type:
- other: estimated data
- Temp.:
- 25 °C
- Remarks on result:
- other: Other details not known
- Transformation products:
- not specified
- Evaporation of parent compound:
- not specified
- Volatile metabolites:
- not specified
- Residues:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Estimated half life of test chemical in sediment was estimated to be 337.5 days (8100 h).
- Executive summary:
Estimation Programs Interface prediction model was run to predict the half-life in sediment for the test chemical. The half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0832%), indicates that test chemical is not persistent in sediment.
Referenceopen allclose all
Mass Amount (percent) |
Half-Life (hr) |
Emissions (kg/hr) |
|
Water |
33.4 |
900 |
1000 |
Fugacity (atm) |
Reaction (kg/hr) |
Advection (kg/hr) |
Reaction (percent) |
Advection (percent) |
|
Water |
2.53e-016 |
911 |
1.18e+003 |
30.4 |
39.4 |
Mass Amount (percent) |
Half-Life (hr) |
Emissions (kg/hr) |
|
Sediment |
0.0832 |
8.1e+003 |
0 |
Fugacity (atm) |
Reaction (kg/hr) |
Advection (kg/hr) |
Reaction (percent) |
Advection (percent) |
|
Sediment |
2.44e-016 |
0.252 |
0.0589 |
0.0084 |
0.00196 |
Description of key information
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 33.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs).However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0832%), indicates that test chemicalis not persistent in sediment.
Key value for chemical safety assessment
- Half-life in freshwater:
- 37.5 d
- at the temperature of:
- 25 °C
- Half-life in freshwater sediment:
- 337.5 d
- at the temperature of:
- 25 °C
Additional information
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 33.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs).However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0832%), indicates that test chemicalis not persistent in sediment.
In addition to this, biodegradation in water and sediment endpoint can also be considered for waiver as per in accordance with column 2 of Annex IX of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
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