Manganese, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-2-naphthalenecarboxylic acid complex

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE CATEGORY APPROACH
Please see the category read-across justification in the category object.

Reason / purpose for cross-reference:

read-across source

Transformation products:

no

Key result

Remarks on result:

other: not hydrolysed at pH 4, 7 and 9

Description of key information

According to structural properties and the results of a hydrolysis study using a structural analogue, hydrolysis is not expected/probable.

Additional information

In a guideline study conducted in compliance with OECD 111, the hydrolysis of a category member (CAS 5281-04-9) as a function of pH was tested. No hydrolysis at pH 4, 7 and 9 was determined (MITI, Japan 1994).

Waiving argument:

According to literature data of Harris (1990), Kollig et al. (1993) and Boethling & Mackay (2000) hydrolysis of the substance is not expected.

 

Justification:

Substance has half-lifes at 25°C of above 1 year

This is the criterion for sufficiently stable substances given in OECD TG 111 indicating that no further hydrolysis testing is required (OECD 2004). Substances with half-lifes at pH 4, 7 and 9 and 25°C definitely above one year are for example NHFG (no hydrolysable functional groups)- and NLFG (no labile functional groups)- compounds according to Kollig et al. 1993 and Wolfe and Jeffers 2000. Important categories of organic substances fulfilling these criteria are listed in table 1. The rationale of this waiving argument is that abiotic hydrolysis is at best very slow under environmentally relevant conditions and thus of minor importance.

As no significant further functional group than the ones listed in table 1 have been identified in the structure(s) of the whole category, hydrolysis is not expecdted.

 

Table 1: Organic chemicals with half-lifes at pH 4 to 9 and 25°C above one year.

Organic substance category	Source
Alkanes	Harris 1990
Alkenes	Harris 1990
Alkynes	Harris 1990
Vinyl chloridea	Kollig et al. 1993, Mabey and Mill, 1978
Benzenes/Biphenyls	Harris 1990
Xylenes	Kollig et al. 1993, Wolfe and Jeffers 2000
Polycyclic aromatic hydrocarbonsb	Harris 1990, Kollig et al. 1993
Halogenated aromatics/PCBs	Harris 1990, Mabey and Mill, 1978
Aromatic nitro compounds	Harris 1990, Kollig et al. 1993
Amines	Kollig et al. 1993
Aromatic amines	Harris 1990, Wolfe and Jeffers 2000
Alcohols	Harris 1990, Kollig et al. 1993
Phenols	Harris 1990
Glycols	Harris 1990
Nitriles	Mabey and Mill 1978
Ethers	Harris 1990, Kollig et al. 1993
Aldehydes	Harris 1990
Ketones	Harris 1990
Carboxylic acids	Harris 1990, Wolfe and Jeffers 2000
Sulfonic acids	Harris 1990

^aand higher chlorinated derivatives.

^bHomo- and heterocyclic species.

References

Boethling RS, Mackay D (2000) Handbook of property estimation methods for chemicals: Environmental health and sciences. Chapter 13. Hydrolysis. CRC Press LLC, Boca Raton, Florida.

 

Harris JC (1990) Rate of hydrolysis. In Lyman WJ, Reehl WF, Rosenblatt, DH (eds.) Handbook of chemical property estimation methods. 3rd edn. ACS Washington.

 

Kollig HP, Ellington JJ, Karickhoff SW, Kitches BE, Long JM, Weber EJ, Wolfe NL (1993) Environmental fate constants for organic chemicals under consideration for EPA’s

hazardous waste identification projects. EPA/600/R-93/132.

 

Mabey W, Mill T. 1978. Critical review of hydrolysis of organic compounds in water under environmental conditions. J Phys Chem Ref Data:383-415.

 

OECD. 2004. OECD Guideline for the testing of chemicals. No 111. Hydrolysis as a function of pH.

 

Wolfe NL, Jeffers, PM. 2000. Hydrolysis. In Boethling RS, Mackay D (eds) Handbook of property estimation methods for chemicals: Environmental and health sciences. CRC Press, LLC, Boca Raton, Florida.