Registration Dossier

Administrative data

Description of key information

Skin irritation: OECD guideline 404 and EU method B.4. GLP. 
Eye irritation: OECD guideline 405 and EU method B.5. GLP.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation: No corrosion or irritation were apparent (all scores 0) following a 4 hours period of exposure to the test item.

Eye irritation:

The results indicate that based upon classification criteria of European Directives concerning the classification, packaging and labelling of dangerous substances (67/548/EEC and subsequent revisions) Dipropylen glycol isobornyl ether (mixture of isomers) is not irritating to eyes.

According to the CLP Regulation, the substance is classified as Eye irritant, Category 2, based on the scores obtained for the corneal opacity (calculated as the mean scores following grading at 24, 48 and 72 h) which are above 1 for the three animals and which fully reverses within the observation period.

 


Effects on eye irritation: irritating

Justification for classification or non-classification

According to the CLP Regulation, the substance is classified as Eye irritant, Category 2, based on the scores obtained for the corneal opacity (calculated as the mean scores following grading at 24, 48 and 72 h) which are above 1 for the three animals and which fully reverses within the observation period.