Registration Dossier
Registration Dossier
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EC number: 619-599-0 | CAS number: 915095-94-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 404) and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
- EC Number:
- 619-599-0
- Cas Number:
- 915095-94-2
- Molecular formula:
- C17 H16 Cl I O2
- IUPAC Name:
- (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
- Reference substance name:
- (S)-3-[4-(2-Chloro-5-iodobenzyl) phenoxy] tetrahydrofuran
- Cas Number:
- 915095-94-2
- Molecular formula:
- C17 H16 Cl I O2
- IUPAC Name:
- (S)-3-[4-(2-Chloro-5-iodobenzyl) phenoxy] tetrahydrofuran
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 3 male
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60min through 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Under the conditions of the study IN00078283 was found to be a non irritant to the skin of rabbits with a Primary Irritation Index score of 0.
- Executive summary:
The Primary Irritation Index (PII) was calculated and determined to be 0.
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