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EC number: 223-054-9 | CAS number: 3710-30-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) = 1.27 - 2.68 mg/L based on QSAR-calculations
Key value for chemical safety assessment
Additional information
The acute toxicity of 1,7 -octadiene to fish was investigated in a study conducted by Evonik (84-0376-DKO). This non-GLP test was carried out as static dose-response test according to DIN 38412, part 15. Golden orfes (Leuciscus idus melanotus) were exposed for 48 h to the nominal test concentrations 10, 13, 16 and 20 mg/L. No analytical verification of the test substance concentrations in the test media was performed. The test duration of 48 h is not in line with today's standards where a test duration of 96 h is recommended. Consequently, the resulting LC50 (48 h) value of 12.5 mg/L (nominal) is not sufficient for the fully evaluation of the acute toxicity of the test substance to fish.
Thus,
short-time toxicity to fish is further investigated by
QSAR-calculations. The resulting LC50-values of the QSAR-calculations
using different models were summarized in the following table:
LC50 (96 h) [mg/L] |
Species |
QSAR-tool |
1.48 |
Not specified |
EPIsuite 4.10 |
1.27 |
Pimephales promelas |
OECD Toolbox |
2.68 |
Poecilia reticulata |
ChemProp / Koenemann |
1.75 |
Pimephales promelas |
ChemProp / Veith et al. |
1.71 |
Pimephales promelas |
ChemProp / van Leeuwen et al. |
The calculated LC50-values are within the range of 1.27 – 2.68 mg/L for different fish species, taking into account a test duration of 96 h. Considering all available data for 1,7 -octadiene, the LC50-value for the test substance is expected to be above 1 mg/L.
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