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Short-term toxicity to fish

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Description of key information

LC50 (96 h) = 1.27 - 2.68 mg/L based on QSAR-calculations

Key value for chemical safety assessment

Additional information

The acute toxicity of 1,7 -octadiene to fish was investigated in a study conducted by Evonik (84-0376-DKO). This non-GLP test was carried out as static dose-response test according to DIN 38412, part 15. Golden orfes (Leuciscus idus melanotus) were exposed for 48 h to the nominal test concentrations 10, 13, 16 and 20 mg/L. No analytical verification of the test substance concentrations in the test media was performed. The test duration of 48 h is not in line with today's standards where a test duration of 96 h is recommended. Consequently, the resulting LC50 (48 h) value of 12.5 mg/L (nominal) is not sufficient for the fully evaluation of the acute toxicity of the test substance to fish.

Thus, short-time toxicity to fish is further investigated by QSAR-calculations. The resulting LC50-values of the QSAR-calculations using different models were summarized in the following table:

LC50 (96 h) [mg/L]




Not specified

EPIsuite 4.10


Pimephales promelas

OECD Toolbox


Poecilia reticulata

ChemProp / Koenemann


Pimephales promelas

ChemProp / Veith et al.


Pimephales promelas

ChemProp / van Leeuwen et al.


The calculated LC50-values are within the range of 1.27 – 2.68 mg/L for different fish species, taking into account a test duration of 96 h. Considering all available data for 1,7 -octadiene, the LC50-value for the test substance is expected to be above 1 mg/L.