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Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Remarks:
Mathematical simulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Data source

Referenceopen allclose all

Title:
IH SkinPerm (v2.04)
Author:
AIHA
Year:
2018
Bibliographic source:
https://www.aiha.org/get-involved/VolunteerGroups/Pages/Exposure-Assessment-Strategies-Committee.aspx
Reference Type:
publication
Title:
Dermal absorption of chemicals: estimation by IH SkinPerm
Author:
Tibaldi R, ten Berge W, Drolet D
Year:
2014
Bibliographic source:
J Occup Environ Hyg.,11(1):19-31

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
IH SkinPerm mathematical tool for estimating dermal absorption

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(piperidinothiocarbonyl) hexasulphide
EC Number:
213-537-2
EC Name:
Bis(piperidinothiocarbonyl) hexasulphide
Cas Number:
971-15-3
Molecular formula:
C12H20N2S8
IUPAC Name:
[(piperidine-1-carbothioylsulfanyl)disulfanyl]disulfanyl piperidine-1-carbodithioate
Specific details on test material used for the study:
Entrance data on the test substance :
-temperature : 25°C
-Molecular weight : 448.82 g/mol
-Vapour pressure : 0.00001 Pa
-Water solubility : 0.1 µg/l
-Log kow : 4.43
-Density : 532 mg/m3
-Melting point : 121 °C

Results and discussion

Percutaneous absorption
Time point:
8 h
Dose:
100
Parameter:
percentage
Absorption:
0 %

Any other information on results incl. tables

Details on the results are presented in the attached document.

Applicant's summary and conclusion

Conclusions:
According to the IH skin perm (QSAR), the dermal absorption of DPTH is 0%.