Anthraquinone

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Case report

Data source

Reference

Reference Type:

publication

Title:

Photodermatitis from anthraquinone

Author:

Menezes F and Valente A

Year:

1988

Bibliographic source:

Contact Dermatitis, 18, 171-172

Materials and methods

Study type:

clinical case study

Endpoint addressed:

other: photodermatitis

Principles of method if other than guideline:

A 40-year-old man, working in the paper pulp industry was seen with sub-acute dermatitis in exposed areas - face, neck, and dorsum of the hands. He was patch tested with standard series, anthraquinone from 2 manufacturers (10% pet.), vegetable allergens and oleoresins. Photopatch tests with a photoallergen tray, the 2 anthraquinones (10%) and Disperse blue 35 (1% pet.) were irradiated with UVA, UVB and visible light.

Test material

Test material information

Constituent 1

Reference substance name:

Anthraquinone

EC Number:

201-549-0

EC Name:

Anthraquinone

Cas Number:

84-65-1

Molecular formula:

C14H8O2

IUPAC Name:

9,10-dihydroanthracene-9,10-dione

Method

Type of population:

occupational

Subjects:

A 40-year-old man, working in the paper pulp industry was seen with sub-acute dermatitis in exposed areas - face, neck, and dorsum of the hands. He reported that the beginning of the dermatitis had almost coincided with the introduction of a new anthraquinone to the industrial process. For the next few months, he stayed away from the section, but any time that he re-entered the area, the dermatitis reappeared, with marked aggravation after sun exposure.

Route of exposure:

dermal

Reason of exposure:

intentional, occupational

Results and discussion

Effectivity of medical treatment:

The patient was changed to another department and the dermatitis cleared completely.

Any other information on results incl. tables

The patient was patch tested with standard series, anthraquinone from 2 manufacturers (10% pet.), vegetable allergens and oleoresins, and all were negative. Photopatch tests with a photoallergen tray, the 2 anthraquinones (10%) and Disperse blue 35 (1% pet.) were irradiated with UVA, UVB and visible light; the only positive (++) reaction was when anthraquinone was irradiated with UVA. A biopsy taken of the positive reaction showed eczema.

Determination of MED to UVA and UVB was normal. Photopatch tests with anthraquinone were performed in 5 controls and were negative. The patient was changed to another department and the dermatitis cleared completely.

Applicant's summary and conclusion

Conclusions:

The only positive (++) reaction was when anthraquinone was irradiated with UVA. A biopsy taken of the positive reaction showed eczema. The patient was changed to another department and the dermatitis cleared completely.

Executive summary:

A 40-year-old man, working in the paper pulp industry was seen with sub-acute dermatitis in exposed areas - face, neck, and dorsum of the hands. The patient was patch tested with standard series, anthraquinone from 2 manufacturers (10% pet.), vegetable allergens and oleoresins, and all were negative. Photopatch tests with a photoallergen tray, the 2 anthraquinones (10%) and Disperse blue 35 (1% pet.) were irradiated with UVA, UVB and visible light; the only positive (++) reaction was when anthraquinone was irradiated with UVA. A biopsy taken of the positive reaction showed eczema. Determination of MED to UVA and UVB was normal. Photopatch tests with anthraquinone were performed in 5 controls and were negative. The patient was changed to another department and the dermatitis cleared completely.