Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

No effects up to the limit of the water solubility of the substance.
EC50 (48 h) = 3160 mg a.i./L (nominal) for Daphnia magna (DIN 38412, part 11)

Key value for chemical safety assessment

Additional information

One study investigating the short-term toxicity of D-Glucose, reaction products with alcohols C16-18 (even numbered) (excess) to aquatic invertebrates is available. In this key study performed according to DIN 38412, part 11 and GLP, Daphnia magna was exposed to nominal concentrations of 100, 300, 1000, 3000 and 10,000 mg/L of a product containing 30% APG and 70% fatty alcohol in a static test design. Analytical verification of the test substance concentrations was attempted by TOC and DOC measurement, but could not be performed successfully as undissolved substance gathered at the water surface. Mortality was observed in the treatments of 10,000 mg/L, and an EC50 (48 h) value of 3160 mg/L (nominal) was reported. However this result could be caused by the agglomeration of undissolved test material at the surface and subsequent low oxygen content in these treatments. Hence it can be concluded that there is no short-term toxicity to aquatic invertebrates up to the limit of the water solubility of the substance (Henkel, 1993).

Another supporting study investigated the short-term toxicity of C18 fatty alcohol to Daphnia magna according to GLP and DIN 38412 part 11 (Henkel, 1992). This data for a category member substance is considered suitable for read-across based on a category approach. The substance was applied at 0, 100, 300, 1000, 3000 and 10,000 mg/L nominal in a static test design, however these concentrations are far above the water solubility limit of the substance. As a result, an EC50 (48 h) value 1700 mg/L was stated (EC0 1000 mg/L, EC100 3000 mg/L). Accordingly it can be confirmed that there is no short-term toxicity to aquatic invertebrates up to the limit of the water solubility of the substance.

This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.