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Long-term toxicity to aquatic invertebrates

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Description of key information

No effects up to the limit of the water solubility of the substance.
EC10 (21 d, immobility) = 1.76 mg a.i./L (nominal) for Daphnia magna (OECD 202 part II) (read-across)

Key value for chemical safety assessment

Additional information

There are no data available on long-term toxicity to aquatic invertebrates of D-Glucose, reaction products with alcohols C16-18 (even numbered) (excess). However, there are reliable data for category member substances which are considered suitable for read-across based on a category approach. 

This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.

The long-term effects of the category member D-Glucopyranose, oligomeric, C10-16-alkyl glycosides towards aquatic invertebrates were evaluated in a 21-d test with Daphnia magna according to OECD guideline 202 part II (Stelter, 1995). The test design was semi-static with a daily renewal of the test substance and growth medium. The test exhibited an EC10 (21 d) value of 1.76 mg a.i./L for the endpoint mortality and a NOEC (21 d) of 2 mg a.i./L for the endpoint reproduction, respectively.

Another supporting study investigated the long-term toxicity of C18 fatty alcohol to Daphnia magna according to GLP and a German UBA toxicity testing proposal equivalent to OECD 211 (Henkel, 1992). The substance was applied at 0, 1, 3, 10, 30 and 100 mg/L nominal in a semi-static test design; however these concentrations are far above the water solubility limit of the substance. As a result, a NOEC (21 d) value of 0.98 mg/L was stated (mortality and reproduction). The results above the limit of solubility should be treated with caution as they may reflect the effects of physical fouling rather than true toxicity of the test substance.

Accordingly it can be confirmed that there is no long-term toxicity to aquatic invertebrates up to the limit of the water solubility of the substance.