Registration Dossier
Registration Dossier
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EC number: 939-266-6 | CAS number: 1179883-13-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP guideline study tested with the source substance D-Glycopyranose, oligometric, C10-16-alkyl glycosides (CAS 110615-47-9). According to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- D-Glucopyranose, oligomeric, C10-16-alkyl glycosides
- EC Number:
- 600-975-8
- IUPAC Name:
- D-Glucopyranose, oligomeric, C10-16-alkyl glycosides
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Physical state: golden pale, viscous liquid
- Analytical purity: no data
- Storage condition: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, USA
- Weight at study initiation: 211-287 g
- Housing: 5 per cage in wire mesh suspension cages
- Diet: PURINA Laboratory Chow, ad libitum (fasted overnight prior to dosing)
- Water: tap water, ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.2 mL/kg bw
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: animals were observed at least twice daily during the study study period. Individual body weights were determined on study initiation, Day 7 and Day 14 (study termination).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured.
- Clinical signs:
- other: No treatment-related changes.
- Gross pathology:
- No treatment-related changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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