Diethyl malonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Range-Finding Toxicity Data: List VII

Author:

Smyth HF, Carpenter CC, Weil CS, Pozzani UC, Striegel JA and Nycum JS

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30, 470-476

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1962

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: as described by Smyth et al., Amer. Ind. Hyg. Assoc. J. 23, 95-107

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Diethyl malonate

EC Number:

203-305-9

EC Name:

Diethyl malonate

Cas Number:

105-53-3

Molecular formula:

C7H12O4

IUPAC Name:

diethyl malonate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

age 4 - 5 weeks
weight 90 - 120 g

Administration / exposure

Route of administration:

other: gastric intubation

No. of animals per sex per dose:

5 per dose

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

15 794 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 value determined by the study is 15.8 g/kg. This value is far above the limit for a classification as acute toxic.