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EC number: 235-557-0
CAS number: 12286-65-6
Information on acute oral and dermal toxicity is partially derived from structural analogues (barium- and calcium-salts). Four studies were performed to evaluate acute oral and dermal toxicity of the test substance to the rat (according or similar to OECD 401, 402). The test substance did not induce any mortalities, abnormalities or clinical signs when applicated oral or dermal. The LD50 for oral and dermal toxicity is considered to be > 10.000 mg/kg bw and > 2000 mg/kg bw, respectively.
Read across justification
The acute oral toxicity of the test substance was not determined.
Thus, it is acceptable to derive information on acute toxicity from
structural analogues since all of the substances are salts and share
high similarity in structure. Moreover, all analogue substances are
minimal soluble in water. A detailed read across justification is given
in Annex I of the CSR.
Procedure and observations
Read across to CAS 12286 -66 -7
To evaluate the acute oral toxicity, single doses of 5000 and
10.000 mg/kg bw of the test article were administrated to groups of male
and female rats by oral gavage (Ciba 1972a). Following dosing, the
animals were observed for 8d. There were no deaths as a result of
treatment with the test article. Clinical signs of toxicity or changes
in body weight gain were not observed during the observation period.
Gross necropsy was without any findings.
In the course of a second study according OECD guideline 401, a single
dose of 15.85 g/kg bw of the test item dissolved in olive oil was
administrated orally to rats (Synthesia 1993). All animals survived
until scheduled necropsy. Any symptoms or clinical signs did not occur. However,
analytical data and purity of the test material were not confirmed by
the provider. Thus, this study is regarded as not reliable.
Read across to CAS 5270 -80 -6
In a limit test similar to OECD guideline 401 a single dose of
5000 mg/kg bw of barium-salt analogue dissolved in
carboxymethyl-cellulose was administrated to rats by gavage (Civa 1980).
The post observation period was 14d and animals were daily checked for
clinical signs and mortalities. All animals survived until scheduled
necropsy, body weights were uneffected by the substance and signs of
toxicity were also not observed. Pathology was without any findings.
The substance was tested for acute dermal toxicity using Wistar rats.
Two groups of animals (5 males and 5 females) received a single dose of
2000 mg/kg bw. The test material was applied onto shaved dorsal skin for
24 hours. The test animals were observed 14 days after exposure of the
test substance, afterwards they were sacrificed, and the necropsy for
macroscopic examination of the organs was performed. The test item did
not cause mortalities. Clinical signs or macroscopic changes were not
Read across to 12286 -66 -7
Oral application of the test substance and a structural analogue
did not induce any signs of toxicity. None of the animals died,
viability and bodyweight gain were unaffected by the test article. Also
dermal application did not induce any symptoms or mortalities. Thus, the
substance is not considered to be toxic after single oral or dermal
Dangerous Substance Directive
The available studies are considered
reliable and suitable for classification purposes under 67/548/EEC. As a
result the substance is not considered to be classified for acute
toxicity under Directive 67/548/EEC, as amended for the 28th time in
Classification, Labelling, and
Packaging Regulation (EC) No. 1272/2008
The available experimental test data
are reliable and suitable for classification purposes under Regulation
1272/2008. As a result the substance is not considered to be classified
for acute toxicity under Regulation (EC) No. 1272/2008, as
amended for the second time in Directive (EC 286/2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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