Registration Dossier
Registration Dossier
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EC number: 227-575-2 | CAS number: 5894-60-0
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 26.3 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: assessment based on the IOEL for hydrochloric acid (8 mg/m3 (8 h TWA) in Commission Directive 2000/39/EC).
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: based on Occupational Exposure Limit (OEL) for HCl (8 h TWA).
- Value:
- 8 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for other interspecies differences:
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for intraspecies differences:
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for the quality of the whole database:
- 1
- Justification:
- Not required as assessment based on OEL.
- AF for remaining uncertainties:
- 1
- Justification:
- Not required as assessment based on OEL.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 49.3 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: based on the indicative Short-Term Exposure Limit (STEL) for HCl.
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- other: based on the STEL for HCl.
- Value:
- 15 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required as assessment based on STEL.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not required as assessment based on STEL.
- AF for other interspecies differences:
- 1
- Justification:
- Not required as assessment based on STEL.
- AF for intraspecies differences:
- 1
- Justification:
- Not required as assessment based on STEL.
- AF for the quality of the whole database:
- 1
- Justification:
- Not required as assessment based on STEL.
- AF for remaining uncertainties:
- 1
- Justification:
- Not required as assessment based on STEL.
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
Although a hazard assessment has been conducted for the respective endpoints for the general population, there is no potential for exposure of consumers via any route to trichloro(hexadecyl)silane.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
