Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-156-6 | CAS number: 34690-00-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No study of toxicity to micro-organisms is available for BHMT-H. A reliable study, performed with a Na/H salt of EDTMP, is available. The EC50 to WWTP micro-organisms was determined to be >100 mg/L as active acid. In view of the low level of inhibition seen at a loading of 100 mg/l, it is acceptable to interpret this value as an EC5. This result comes from a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
5.4% inhibition was seen at 100 mg/L loading (in terms of active acid), thus the EC50 is >100 mg/l. No NOEC or EC5 was derived by the report authors, however in view of the low level of inhibition (approximately 5%) seen at a loading of 100 mg/l, it is considered acceptable to interpret this concentration as an approximation of the EC5 for the purpose of PNEC derivation.
There is no data available for the toxicity of BHMT to aquatic microorganisms, therefore data have been read-across from structural analogue, EDTMP.
BHMT acid (CAS 34690-00-1) has three amine centres (five methylphosphonate groups), connected by hexyl chains. EDTMP acid (CAS 1429-50-1) has two aminobismethylphosphonate groups, connected by an ethyl chain.
As well as being structural analogues, both phosphonates have consistent chemical properties including high MW (685 and 436 respectively), very low log Kow(≤-4 for both substances) and are highly soluble in water. The substances generally posses similar physico-chemical properties and are not readily biodegradable.
The sodium counterion of EDTMP-xNa (22036-77-7) is not significant in respect of the properties under consideration and has been assessed in depth in the public literature.Additionally, the counterion is expected to dissociate when in contact with water, including atmospheric moisture.
Therefore, for the purpose of this assessment, read-across is considered valid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
