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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meetd basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
4653-59-0
IUPAC Name:
4653-59-0
Details on test material:
Name of the test substance used in the study report: 4-Chlorbuttersäurechlorid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
Fasting period: 15 - 20 h before administration
Application volume: 5 ml/kg
Doses:
215, 1000, 1470, 2150, 4640 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: after 2-4 d, 7 d and 13 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 350 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
1 500 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
1 210 mg/kg bw
Mortality:
Male animals:
215, 1000 mg/kg: no mortalities after 14 days
1470 mg/kg: 2/5 after 14 days
2150 mg/kg and 4640 mg/kg: all animals within 14 days

Female animals:
215 mg/kg: no deaths after 14 days
1000 mg/kg: 1/5 after 14 days
1470 mg/kg: 4/5 after 14 days
2150 and 4640 mg/kg: all animals died within 14 days
Clinical signs:
other: 1000, 1470, 2150 and 4640 mg/kg: dyspnea, apathy, abnormal position, staggering, atonia, pain reflexes missing, narcotic-like state, tremor, ruffled fur, exsiccosis, paresis, poor general state.
Gross pathology:
Animals that died: acute dilatation of the heart atrium; acute congestive hyperemia; liver: manifold slightly broadened peripheral lobule painting; stomach: manifold hemorrhagic corrosive scab formation; intestine: diffuse reddened mucosa.
Sacrificed animals - up to 1000 mg/kg: no abnormalities. 1470 mg/kg: stomach: top of the gastro-esophageal vestibule partly thickened and partly button formation; adhesions of the forestomach with the spleen, liver and peritoneum.

Applicant's summary and conclusion