Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, essential details given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorobutyryl chloride
EC Number:
225-059-1
EC Name:
4-chlorobutyryl chloride
Cas Number:
4635-59-0
Molecular formula:
C4H6Cl2O
IUPAC Name:
4-chlorobutanoyl chloride
Details on test material:
Name of the test substance used in the study report: gamma-Chlorbuttersäurechlorid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact skin
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
ca. 1 ml
Duration of treatment / exposure:
1 min, 5 min, 15 min, 20 h
Observation period:
3 days
Number of animals:
2
Details on study design:
Patch test (length: 2.5 x 2.5 cm)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: erythema score for 1 min exposure
Basis:
mean
Time point:
other: 24h - 3d
Score:
2
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
other: erythema score for 5 min exposure
Basis:
mean
Time point:
other: 24h - 3d
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: necrosis
Irritation parameter:
other: erythema score for 15 min exposure
Basis:
mean
Time point:
other: 24h - 3d
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: strong necrosis
Irritation parameter:
other: erythema score for 20 hours exposure
Basis:
mean
Time point:
other: 24h - 3d
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: strong necrosis
Irritant / corrosive response data:
Due to animal welfare, the experiment was stopped after 3 days.

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information