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Long-term toxicity to aquatic invertebrates

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Description of key information

21-d EC10 (reproduction): 0.15 mg/L

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.15 mg/L

Additional information

In the Klimisch 1 GLP study from Eckenstein (2015) the chronic toxicity of Butanedioic acid, sulfo-, 1,4-diisodecyl ester, sodium salt on Daphnia magna was determined in an 21 day semi-static test according to OECD 211. The test was performed with Control, 0.042 (n.a.), 0.084 (n.a.), 0.17 (0.052), 0.34 (0.15), 0.67 (0.40) and 1.3 (0.76) mg sulfosuccinate/L. The biological results are based on mean measured sulfosuccinate concentrations (calculated as the time-weighted means over all measurements per test concentration with food). The mean measured values are presented in brackets behind the nominal concentrations.

Ten replicates with 1 Daphnia each were set up. After 21 days 0, 0, 0, 0, 0, 40 and 100% mortality was observed in the control and at nominal test concentrations of 0.042 (n.a.), 0.084 (n.a.), 0.17 (0.052), 0.34 (0.15), 0.67 (0.40) and 1.3 (0.76) mg sulfosuccinate/L, respectively. The mean measured values are presented in brackets behind the nominal concentrations.

The reproduction per parent Daphnia was 109.4 (9), 112.0 (10), 108.3 (10), 128.2 (10), 75.7 (10), and 74.8 (10) living offspring per parental animal (number of parental daphinds used to calculate the mean are given in brackets) in the control and 0.042 (n.a.), 0.084 (n.a.), 0.17 (0.052), 0.34 (0.15), 0.67 (0.40) mg sulfosuccinate/L, respectively. The mean measured values are presented in brackets behind the nominal concentrations. Due to 100 % mortality at 1.3 (0.76) mg/L until day 1, there was no reproduction in the highest test concentration group.

 

The biological results were based on time weighed mean measured concentrations.

 

The EC10 for mortality is 0.31 mg/L, the EC10 for reproduction is 0.15 mg/L, the EC10 for growth is > 0.40 mg/L. For the risk assessment, the more conservative EC10, i.e., the EC10 for reproduction was used.

 

The result is considered relevant and reliable for the risk assessment.