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Toxicity to microorganisms

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Description of key information

OECD 209: 3 h EC50: > 650 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
650

Additional information

In the Klimisch 2 study from Noack (1991) the respiration inhibition of Netzer SB 10 (which contains 65% a.i.) to activated sludge was determined in a 3 h static GLP respiration inhibition test according to OECD 209. The nominal test concentrations were 0 (control), 32, 100, 180, 320, 580 and 1000mg Netzer SB 10/L, corresponding to 0 (control), 20.8, 65, 117, 208, 377 and 650 mg a.i./L. Two control replicates were set up. Dose verification analysis was not performed. The respiration was measured using an oxygen probe. The EC20, EC50 and EC80 was calculate by regression of the log transformed concentration vs. probit transformed percent inhibition relative to the average control respiration. The EC20 and EC50 were 130 and > 1000 mg Netzer SB 10 /L, respectively. These values correspond to EC20 and EC50 values of 84.5 and > 650 mg a.i./L.

This study is considered to be acceptable for the risk assessment.