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EC number: 607-997-7 | CAS number: 26776-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-07-18 to 2002-09-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- Directive 92/69/EEC
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis at beginning and end of test (0 and 48 h)
- Vehicle:
- no
- Details on test solutions:
- - Concentration: 1 g/l stirred in deionized water for 18 hours and filtered, no vehicle or solvent; analytical concentration 0.37 mg/l
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Strain: Daphnia magna Straus, clone 5
- Source/supplier: Infracor GmbH (inhouse)
- Breeding method: In 1 l beakers with M4 medium (Elendt,
1990), water renewal each 2-3 days, isolation of offspring
for further breeding each ca. 4 weeks
- Age: < 24 hours
- Feeding: Desmodesmus subspicatus, daily as much as
consumed
- Pretreatment: Separation from adults 24 h prior to testing
- Feeding during test: none
- Control group: 2 reference substance controls (1.0 and 2.0
mg/l), one blank - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 d
- Test temperature:
- 20.16 - 21.54 (mean 20.41) degree C
- pH:
- 7.7 - 7.8
- Dissolved oxygen:
- 7.6 - 8.0 mg/l
- Nominal and measured concentrations:
- - Concentrations: (analytical) 0.33 mg/l (0 hours) / 0.36 mg/l (48 hours)
- Details on test conditions:
- TEST SYSTEM
- Exposure vessel type: round-bottom test tubes with 10 ml
- Number of replicates, individuals per replicate:
4 replicates with 5 individuals each
DILUTION WATER
- Source: Synthetic:
CaCl2 x 2 H2O: 294 mg/l
MgSO4 x 6 H2O: 114 mg/l
NaHCO3: 65 mg/l
KCl: 6 mg/l
- Ca/Mg ratio: 4:1
- Na/K ratio: 10:1
- Hardness: 14 degree dH = 250 mg CaCO3/l
- Aeration: none - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.33 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- At the highest concentration which could be achieved under the conditions (water solubiilty limit) of the test no negative effect could be observed.
- Effect data (Immobilisation): No. of immobile daphnia
Control: 0 (24 h) / 0 (48 h)
Exposed: 0 (24 h) / 0 (48 h) - Results with reference substance (positive control):
- - Concentrations: 1.0 mg/l / 2.0 mg/l
- Results: 35 % immobile / 100 % immobile (24 hours) - Validity criteria fulfilled:
- yes
- Conclusions:
- No effects were observed up to the water solubility limit (0.33 mg/L) indicating that 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane does not pose a significant hazard to aquatic invertebrates.
- Executive summary:
The acute toxicity of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane to Daphnia magna was studied under static conditions according to OECD TGD 202 and EU method C2. Daphnids were exposed to the test substance at a saturated stock solution for 48 h. No effects were observed up to the water solubility limit (0.33 mg/L) and thus the EC50 was determined to be >0.33 mg/L. This indicates that the test substance does not pose a significant hazard to aquatic invertebrates. The study was assessed as "reliable without restrictions".
Reference
Description of key information
The acute toxicity of the test substance to Daphnia magna was studied under static conditions according to OECD TGD 202 and EU method C2. Daphnids were exposed to the test substance at a saturated stock solution for 48 h. No effects were observed up to the water solubility limit (0.33 mg/L) and thus the EC50 was determined to be >0.33 mg/L. This indicates that the test substance does not pose a significant hazard to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- limit of water solubility
- Effect concentration:
- > 0.33 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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