Registration Dossier
Registration Dossier
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EC number: 223-829-1 | CAS number: 4090-51-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Relevant methodological deficiencies (only 4 h of exposure, only 4 animals)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- acute dermal irritation and toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
- EC Number:
- 223-829-1
- EC Name:
- 2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide
- Cas Number:
- 4090-51-1
- Molecular formula:
- C10H20O5P2S2
- IUPAC Name:
- 2,2'-oxybis(5,5-dimethyl-1,3,2-dioxaphosphinane) 2,2'-disulfide
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: exposure duration 4 h
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the LD50 in male rats was > 5000 mg/kg. Due to relevant methodological deficiencies (only 4 h of exposure, only 4 animals), no definite conclusions can be drawn.
- Executive summary:
4 rats of unknown sex were treated with 5000 mg/kg test substance (occlusive) for 4 h and observed for 14 days. No mortality and no other effects were reported. Therefore under the conditions of this study the LD50 in rats was > 5000 mg/kg.
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