Registration Dossier
Registration Dossier
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EC number: 234-196-6 | CAS number: 10591-84-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reporting in brief but sufficient information for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Single application of 50 mg testsubstance into the conjunctival sac of one eye of each of 2 rabbits; observation time: 7 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N'-dimethyldiphenylthiuram disulphide
- EC Number:
- 234-196-6
- EC Name:
- N,N'-dimethyldiphenylthiuram disulphide
- Cas Number:
- 10591-84-1
- Molecular formula:
- C16H16N2S4
- IUPAC Name:
- N-methyl-N-phenyl{[methyl(phenyl)carbamothioyl]disulfanyl}carbothioamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- purity: 98.1%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- body weight at study initiation: 3-4 kg
male and female
housing individually
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye of each of the 2 rabbits
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- no data specified
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- Single application of 50 mg testsubstance into the conjunctival sac of one eye of each of 2 rabbits; observation time: 7 days
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: at the end of the 7 day observation period
- Score:
- ca. 0
- Reversibility:
- other: the substance caused no irritation
- Irritant / corrosive response data:
- the substance caused no irritation
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Single application of 50 mg testsubstance into the conjunctival sac of one eye of each of 2 rabbits; observation time: 7 days.
Vulcacit I caused no irritation (Mihail 1977)
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