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Description of key information

Parent compound butyryl chloride: In contact with water the substance will hydrolyse rapidly.
Hydrolysis product butyric acid: The substance is readily biodegradable.

Key value for chemical safety assessment

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of butyryl chloride (CAS 141-75-3) (Q)SAR results were used for hydrolysis. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, further experimental studies on hydrolysis are not provided.



Parent compound butyryl chloride (CAS 141-75-3):

HYDROWIN v2.00 data indicate that acyl halides, like butyryl chloride, usually have hydrolytic half-lives of less than 10 minutes (EPISuite v4.11, BASF SE, 2022).

Butyryl chloride hydrolyses rapidly and forms butyric acid and hydrochloric acid. Hydrochloric acid is inorganic. Butyric acid does not decompose by hydrolysis under environmental conditions due to its chemical structure.


Hydrolysis product butyric acid (CAS 107-92-6):

According to Regulation (EC) 1907/2006, Annex VIII, Section, Column 2, a study on hydrolysis does not need to be conducted if the substance is readily biodegradable or inorganic. Butyryl chloride hydrolyses rapidly and forms butyric acid and HCl. Butyric acid is readily biodegradable (CATALOGIC v5.15.2, OECD 301C v12.17, BASF SE, 2022; see IUCLID Ch. 5.2.1), while HCl is inorganic.