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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Parent compound butyryl chloride: No data available.
Hydrolysis product butyric acid: No data available, therefore the risk assessment based on read-across to the structurally similar substance isobutyric acid.
Isobutyric acid: Acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Effect concentration:
51.25 mg/L

Additional information

In aquatic systems, butyryl chloride (CAS 141-75-3) hydrolyses quickly and forms HCl (CAS 7647-01-0) and butyric acid (CAS 107-92-6) (for details see section 5.1.2).


Parent compound butyryl chloride and hydrolysis product butyric acid:

No data are available for butyryl chloride (CAS 141-75-3) and butyric acid (CAS 107-92-6). Therefore, the short-term toxicity to aquatic invertebrates is assessed via read across to the structurally similar substance isobutyric acid (CAS 79-31-2).


Isobutyric acid (CAS 79-31-2):

The acute toxicity to Daphnia magna was determined in a non-GLP study following the German Industrial Standard DIN 38412, part 11 (similar to OECD 202). The 48h EC50 was reported to be 51.25 mg/L (BASF, 1989, 1/0244/2/89-0244/89).

The test concentrations were not analytically  monitored. However, it is assumed that the test item remained stable over the exposure period based on a high water solubility (618 g/L, OECD 105, OXEA, 2009), a low vapour pressure (2 hPa at 20 °C, OXEA, 2009) a low Henry's Law constant (0.098 Pa*m³/mol, HENRYWIN v3.20, BASF SE, 2022) and a low adsorption potential (log Kow = 1.1, OXEA, 2009; log Koc = 1.66 according to Franco&Trapp, BASF SE, 2022).



Taking into account the results of isobutyric acid the test substance butyryl chloride and its hydrolysis product butyric acid are expected to be acutely harmful to aquatic invertebrates.