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Short-term toxicity to aquatic invertebrates

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Description of key information

Parent compound butyryl chloride: No data available.
Hydrolysis product butyric acid: No valid data available, therefore the risk assessment based on read-across to the structurally similar substance isobutyric acid.
Isobutyric acid: Acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
51.25 mg/L

Additional information

Parent compound butyryl chloride:

No data are available for butyryl chloride (CAS 141 -75 -3). The substance rapidly decomposes in water and forms HCl (CAS 7647 -01 -0) and butyric acid (CAS 107 -92 -6). Therefore, the short-term toxicity to aquatic invertebrates is assessed via read across to the hydrolysis product butyric acid (CAS 107 -92 -6) and the structurally similar substance isobutyric acid (CAS 79 -31 -2).

Hydrolysis product butyric acid:

For the hydrolysis product butyric acid no valid experimental data are available. Results as cited in Onitsuka et al. (1989) and Bringmann & Kühn (1982) are not suitable since exposure duration is 24h instead of 48h. Nevertheless, the study of Bringmann & Kühn can be used to show that the toxicity of butyric acid to Daphnia magna is likely influenced by pH effects due to pH-shift in the medium. Tested under not neutralized conditions the observed 24 -h EC50 was determined to be 55 mg/L. When the test medium was neutralized the obtained 24 -h EC50 was 1950 mg/L.

Isobutyric acid:

With the structurally similar substance isobutyric acid (CAS 79 -31 -2) the acute Daphnia toxicity was tested in a non-GLP study following the German Industrial Standard DIN 38412, part 11 (similar to OECD 202). The EC50 (48-h) was reported as 51.25 mg/L (BASF, 1989, 1/0244/2/89-0244/89).

Taking into account the results of isobutyric acid the test substance butyryl chloride and its hydrolysis product butyric acid are expected to be acutely harmful to aquatic invertebrates.

Hydrolysis product hydrochloric acid (HCl):

The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 withDaphnia magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; OECD 2002).

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