2-(propyloxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

A group of five male rats was given repeated six hour exposures to 100 ppm for a total of 12 exposures. A sixth rat was included as a
sentinel only from which blood samples were taken daily immediately after exposure.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(propyloxy)ethanol

EC Number:

220-548-6

EC Name:

2-(propyloxy)ethanol

Cas Number:

2807-30-9

Molecular formula:

C5H12O2

IUPAC Name:

2-(propyloxy)ethanol

Details on test material:

-Name of test material (as cited in study report): 2-Propoxyethanol

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

not specified in the report

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

not specified in the report

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 6 - ca. 7 h

Concentrations:

273-2132 ppm

No. of animals per sex per dose:

5 rat/dose and a total of 20 rats

Control animals:

yes

Details on study design:

- Duration of observation period following administration: not specified in the report
- Frequency of observations and weighing: Blood samples were taken from one animal i n each group hourly during exposure and at intervals up to
two weeks following exposure.
- Necropsy of survivors performed: not specified in the report
- Other examinations performed: Hemoglobin concentration and hematocrit; gross hemolysis was also observed at concentrations
greater than 1100 ppm.

Statistics:

No data

Results and discussion

Preliminary study:

No data

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 2 132 other: ppm (nominal)

Exp. duration:

6 h

Mortality:

no data

Clinical signs:

other: A red discolored urine was observed in all animals at concentrations of 1100 ppm and greater. Hemoglobin concentration and hematocrit were reduced a t all levels tested, 273- 2132 ppm. In addition, gross hemolysis was also observed at concentrations grea

Body weight:

no data

Gross pathology:

no data

Other findings:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: other: EU GHS

Conclusions:

Based on the study results the LC 50 value was > 2132 ppm (9.061 mg/l, based on molecular weight of 104.15) in the male rats. According to the EU CLP regulations (GHS Criteria), the substance would be classified in Toxicity Category III.

Executive summary:

2-Propoxyethanol was evaluated for acute inhalation test using rats. A total of 20 rats were used, 5 at each dose level. Rats were exposed for 6 hours to the vapor of test chemical in the range of 273-2132 ppm.

A red discolored urine was observed in all animals at concentrations of 1100 ppm and greater. Hemoglobin concentration and hematocrit were reduced a t all levels tested, 273- 2132 ppm. In addition, gross hemolysis was also observed at concentrations greater than 1100 ppm. Tie severity of these blood changes increased as a function of both concentration and length of exposure. Hemolysis was no longer detected 24 hours a f t e r exposure and hemoglobin concentration and hematocrit returned to control levels within two weeks after exposure.

Based on the study results the LC 50 value was > 2132 ppm (9.061 mg/l, based on molecular weight of 104.15) in the male rats.