2,2'-p-phenylenedioxydiethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

However was subject to Quality Assurance

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-p-phenylenedioxydiethanol

EC Number:

203-197-3

EC Name:

2,2'-p-phenylenedioxydiethanol

Cas Number:

104-38-1

Molecular formula:

C10H14O4

IUPAC Name:

2,2'-[1,4-phenylenebis(oxy)]diethanol

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: 0.5% aqueous guar gum

Doses:

5000mg/kg

No. of animals per sex per dose:

5 males and 5 females

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

None

Clinical signs:

other: None observed

Gross pathology:

No treatment related changes observed

Applicant's summary and conclusion

Interpretation of results:

other: CLP criteria (Reg 1272/2008) are not met

Conclusions:

The oral oral LD50 >5000 mg/kg to rats.