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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
O.5 g of substance was applied to the skin of 5 guinea pigs for 24 hours under an occlusive dressing.
GLP compliance:
no
Remarks:
However was subject to Quality Assurance

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-p-phenylenedioxydiethanol
EC Number:
203-197-3
EC Name:
2,2'-p-phenylenedioxydiethanol
Cas Number:
104-38-1
Molecular formula:
C10H14O4
IUPAC Name:
2,2'-[1,4-phenylenebis(oxy)]diethanol

Test animals

Species:
guinea pig
Strain:
other: Cr1:(HA) BR Hartley

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Remarks:
Moistened with water
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
24 hours
Observation period:
15 days
Number of animals:
5 Females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24/48 hours
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 15 days
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritant / corrosive response data:
No signs of irritation were observed over the 15 day observation period

Applicant's summary and conclusion

Interpretation of results:
other: CLP criteria (Reg 1272/2008) are not met
Conclusions:
HQEE was not irritating to guinea pig skin.