Reaction mass of 2-ethyl-2-[[3-(2-methylaziridin-1-yl)propionyl]methyl]propane-1,3-diyl bis(2-methylaziridine-1-propionate) and 2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]propanoate

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Publication describing two case studies.

Data source

Reference

Reference Type:

publication

Title:

Allergic contact dermatitis from aziridine crosslinker cx100

Author:

Ibbotson SH, Lawrence CM

Year:

1994

Bibliographic source:

Contact Dermatitis, 30, 306-307.

Materials and methods

Study type:

clinical case study

Endpoint addressed:

skin sensitisation

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate

EC Number:

939-180-9

Molecular formula:

Not relevant - Multiconstituent substance

IUPAC Name:

2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate

Results and discussion

Results of examinations:

Contact dermatitis due to occupational exposure to adhesives.

Any other information on results incl. tables

15 Printers working in a factory that printed self-adhesive labels, showed 2 cases of skin sensitisation:

Case no. 1

A 43 -y old man working in a factory that printed self-adhesive labels developed rash on his face, arms and body, seven months after the onset of his current work (with 27 years working as water-based printer). The rash improved whilst off work, but recurred within 2 days of return. Examination revealed a severe acute, vesicular eczema of the dorsum and palms of the hands, fingers, head and neck.

Case no.2

A 57 -y old man working in a factory that printed self-adhesive labels developed a rash, five months after the onset of his current work (worked as a printer all his adult life). The rash improved whilst he was off work. On examination eczema of the upper and lower arms, hands, fingers, trunk, head and neck was evident.

Both had no history of atopy or skin disorder and were receiving no medication.

Patch testing was performed on the cases. Case no. 1 reacted to thiuram (1%), while both cases gave positive reactions to crosslinker cx100 (0.1%) at 3 days.

Strict avoidance of direct skin contact will be required to prevent further allergic contact dermatitis.