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Physical & Chemical properties

Water solubility

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Description of key information

OECD 105, flask method, GLP, key study, validity 1:
Water solubility = 63.25 g/L at 20°C.
Very soluble in water.

Key value for chemical safety assessment

Water solubility:
63.25 g/L
at the temperature of:
20 °C

Additional information

One key study is available to determine the water solubility of the test item applying the procedure described in the OECD Guideline 105 with GLP statement. As the water solubility was expected to be near 50 g/L for the test item, it appeared that the flask method was best suited. The test is run at 20 +/- 0.5°C (between 19.6 and 20.1°C). Six 250 mL Schott flasks were used to mix 6 x 25 g of the test item with 100 mL of ultrapure water. Flasks were placed in a temperature controlled oven at 30°C under magnetic stirring. After 24 hours, two flasks were removed and placed in another temperature controlled oven at 20 +/- 0.5°C during 24 hours. After separation of the insoluble upper part by decantation, the concentration of the test item in the clear aqueous phase was then determined following the analytical method (HPLC/UV, detection limit of the method is 0.26 g/L and quantification limit is 0.87 g/L). The other flasks were treated similarly after initial equilibration at 30°C for 2 and 3 days respectively.

Water solubility results of each replicate are presented below:

- T.24h: test item concentration 61.0 -66.1 g/L (pH: 3.48 -3.48);

- T.48h: test item concentration 61.2 -62.5 g/L (pH: 3.46 -3.44);

- T.72h: test item concentration 64.0 -64.7 g/L (pH: 3.50 -3.45).

As required by the guideline, the concentrations measured in the 2 last vessels don't differ by more than 15%. Thus, as shown by these results, the water solubility of the test item is 63.25 g/L.