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EC number: 700-071-4
CAS number: 932742-30-8
- The method used is not intended to allow
calculation of a precise LD50 value, but an LD50 value is assigned,
according to the OECD Guideline No.423 and Comission Regulation (EC) No
440/2008, Annex Part B, B.1.tris: "Acute Oral Toxicity – Acute Toxic
Class Method", Official Journal of the European Union No. L 142, dated
May 31st, 2008.
The acute toxicity oral of SIKA Hardener LI
was examined by an acute toxic class method according to the OECD
Guideline 423 and the EU method B.1. Two groups of three female Wistar
rats were treated with SIKA Hardener LI by a single oral administration
by gavage at a dose levels of 2000 mg/kg bw using Polyethylene glycol as
a vehicle. The concentration of the formulations in Polyethylene Glycol
was 200 mg/mL administered by a constant treatment volume of 10 mL/kg
bw. Based on the results of the study and according to the criteria of
the relevant test guidelines no further testing was performed.
No mortalities were recorded. No clinical
signs were observed under the duration of the 14 days observation
The body weight gain of the animals was
considered to be normal with no indication of test item related effect.
The macroscopic examination revealed some
minor alterations as mottled pale areas in the liver, diffuse dark red
discolouration of the lung, dark focus on the lung and collapsed lung.
Additionally uterus in oestrus was recorded in one animal.
All of the changes listed below were
considered to be agonal or incidental.
Under the conditions of the present study, a
single oral administration of the test item SIKA Hardener LI at the dose
level of 2000 mg/kg bw did not cause any treatment related adverse
effects. Thus, the LD0 value and LD50 values assigned were 2000 mg/kg bw
and > 2000 mg/kg bw, respectively.
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