Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Ready biodegradability test of GRILBOND IL-6 100 % was performed according to OECD guideline 301B under GLP compliance. The test item GRILBOND IL-6 100 % of EMS-Chemie AG achieved - 0.66 % biodegradation in 28 days (10 days window: not applicable) and an abiotic degradation of 8.7 % in a CO2 Evolution Test conducted according to OECD-Guideline 301 B. Thus, the test item GRILBOND IL-6 100 % is not readily biodegradable.

In accordance with Column 2 of REACH, Annexes VIII the tests do not need to be conducted if the substance is highly insoluble in water (water solubility: 8.22 µg/L). Thus, no additional hydrolysis test was required.

The BCF value has been available by the QSAR. The logBCF is 2.62 (BCF: 414.2 L/Kg). Thus, no further testing will be necessary.

The logKOC value has been calculated by the software of KOCWIN v.2.00. The logKOC is 3.92 estimated from MCI and 3.57 estimated from logKOW.

Since exposure of environment to the substance is extremely unlikely as during manufacturing, formulation and industrial processes all wastes, including gas emissions, water and solid waste, are incinerated in approved incineration plants, as described in section 3.5. Thus, no additional tests are necessary.