Registration Dossier
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EC number: 700-958-6 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely very toxic to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
The acute toxicity to Daphnia magna was determined in a 48 -hour static test according to OECD Guideline 202 (RCC Notox BV, 1993g). The test was performed in compliance with Good Laboratory Practice Regulations. The test item was not soluble in water. Hence, the dispersing agent Cremophor RH40 was used to prepare stable dispersions of the test item in water. Daphnia were exposed for a maximum of 48 hours to a range of solutions containing 1.0 to 100 % of a filtrate of a supersaturated solution of 1000 mg/L (nominal).
After 24 hours of exposure significant (>10 %) immobilization was recorded at 1.1 mg/L (10 % filtrate) and higher concentrations. The total rate of immobilization was 15 % at 1.1 mg/L (10 % filtrate), 30% at 3.5 mg/L (18 % filtrate) and 100 % at higher concentrations. After 48 hours of exposure immobilization of all daphnia was seen at concentrations of 3.5 mg/L (18 % filtrate) and higher. At 1.1 mg/L (10 % filtrate) the total incidence of immobility had increased to 80 % and at 1.0 mg/L (5.6 % filtrate) to 40 %. Exposure of daphnia to lower concentrations during the second part of the test induced no significant (> 10 %) immobility after 48 hours.
Under the conditions of the present study, the test item did not induce acute immobilization of Daphnia magna at or below 0.6 mg/L after 48 hours of exposure (NOEC) with a 48 hour EC50 of 0.97 mg/L.
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