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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium manganese(3+) diphosphate
EC Number:
233-257-4
EC Name:
Ammonium manganese(3+) diphosphate
Cas Number:
10101-66-3
Molecular formula:
MnNH4P2O7
IUPAC Name:
ammonium manganese(3+) diphosphate
Details on test material:
Lot X-1426

Test animals

Species:
rat
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200-300 g
- Fasting period before study: yes, fasted for 24 h

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Doses:
4000, 8000, 10000, 12500, 16000, 20000 and 32000 mg/kg
No. of animals per sex per dose:
Five animals per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: Two weeks
- Frequency of observations: Animals were observed daily.
- Necropsy of survivors performed: No postmortem, or histopathology examinations were performed in this particular study.

Results and discussion

Effect levelsopen allclose all
Key result
Dose descriptor:
LD50
Effect level:
12 900 mg/kg bw
Based on:
test mat.
95% CL:
11 500 - 14 400
Dose descriptor:
LD0
Effect level:
10 000 mg/kg bw
Based on:
test mat.
Clinical signs:
Ruffled, unkempt coats were evident at 4000 mg/kg.
Lethargy, unkempt coats and nasal hemorrhage were prevalent in the animals dosed at 8000 mg/kg and 10000 mg/kg.
Staggering gait, impaired locomotion, lethargy and nasal hemorrhage were noted at levels of 12500 mg/kg and above. Comas preceded death in the animals which succumbed.
Equally toxic to male and females.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 was determined to be 12900 mg/kg.
Executive summary:

An acute oral toxicity was performed using albino male and female rats. The oral LD50 was determined to be 12900 mg/kg (95% confidence limits = 11500 -14400 mg/kg).

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