Registration Dossier
Registration Dossier
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EC number: 201-936-4 | CAS number: 89-75-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10/1986 - 12/1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EG-Guidline B.4 Akute Toxizität Hautreizung der Richtlinie 84/449/EWG
- Qualifier:
- according to guideline
- Guideline:
- other: Richtlinie 83/467/EWG: Richtlinie der Kommission vom 29.Juli.1983
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Benzoylchloride, 2,4-dichloro-
- IUPAC Name:
- Benzoylchloride, 2,4-dichloro-
- Reference substance name:
- 2,4-dichlorobenzoyl chloride
- EC Number:
- 201-936-4
- EC Name:
- 2,4-dichlorobenzoyl chloride
- Cas Number:
- 89-75-8
- Molecular formula:
- C7H3Cl3O
- IUPAC Name:
- 2,4-dichlorobenzoyl chloride
- Test material form:
- other: liquid
- Details on test material:
- Content: 99%
Colour:Colourless
The material should be stored at 22 °C under the hood (dark)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Age of the animals: 3-5 months, BW: 1,7-3,1 kg,ID: Ear tagged; Origin: Hoechst AG ,Kastengrund, conventional breeding
Humidity: 50+/- 20 % , Room temperatur:20+/-3 °C , 12/12 h light/dark, individual housing, Feeding: Altromin 2123 Haltungsdiet-Kaninchen Altromin-GmbH, Lage/Lippe, ad libitum plus hay,water (chlorinated) was given ad libitum.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 h and 3 minutes exposure
- Observation period:
- 21 days observation
- Number of animals:
- 3 animals per group
- Details on study design:
- The animals were shaved (with an electronic shaver; 25 m2 dorsal of the hull) 24 hours before the experiment was accomplished.Only animals with
an intact skin were used. Every animal was patched with a plaster and a 2.5x2.5 cm cellulose. Under the plaster 0.5 ml of the substance was
administered and ligated with a semiocclusive bandage. The exposure time was 4 h and 3 minutes. After exposure the substance was removed with lukewarm water. The assessment followed after 30-60 minutes, 24h, 48 h and 72 h, 7, 14 and 21 days after the plaster was removed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on this study the chemical substance 2,4-Dichlorobenzoyl chloride was classified as corrosive.
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