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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of various test chemicals
Justification for type of information:
Experimental data of various test chemicals is from handbook or collection of data
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE is based on the toxicity study of two studies on Tetrahymena pyriformis.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Tetrahymena pyriformis
Details on inoculum:
Study 2 and 3 :Cultures are reared in 50 m L of a sem i -defined medium 250-m L Erlenmeyer flasks.
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
40 h
Test temperature:
2&3: 27±1°C
Nominal and measured concentrations:
2&3: Nominal 5 concentrations were taken
Reference substance (positive control):
not specified
Key result
Duration:
40 h
Dose descriptor:
other: ICG50
Effect conc.:
0.102 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other:
Remarks:
not known
Duration:
40 h
Dose descriptor:
other: ICG 50
Effect conc.:
0.13 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other:
Remarks:
Not known
Validity criteria fulfilled:
not specified
Conclusions:
The effect of the test chemical was studied on the Tetrahynema pyriformis, the range of ICG50 was determined to be from 0.102 - 0.130 mg/L
Executive summary:

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on microorganisms. The studies are as mentioned below:

Both The study was conducted to evaluate the toxic effects of the test chemical on the microorganism Tetrahynema pyriformis. The test was conducted for the period of 40-h in static conditions. Five different concentrations were taken to evaluate the ICG 50, median inhibition growth concentration. Test was conducted in the replicates and the growth inhibition was recorded using spectrophotometrically.Based on the results obtained from the experiment the ICG 50 range was from0.102 - 0.130 mg/L

Description of key information

The study was conducted to evaluate the toxic effects of the test chemical on the microorganism Tetrahynema pyriformis. The test was conducted for the period of 40-h in static conditions. Five different concentrations were taken to evaluate the ICG 50, median inhibition growth concentration. Test was conducted in the replicates and the growth inhibition was recorded using spectrophotometrically.Based on the results obtained from the experiment the ICG 50 range was from0.102 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
0.102 mg/L

Additional information

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on microorganisms. The studies are as mentioned below:

Both The study was conducted to evaluate the toxic effects of the test chemical on the microorganism Tetrahynema pyriformis. The test was conducted for the period of 40-h in static conditions. Five different concentrations were taken to evaluate the ICG 50, median inhibition growth concentration. Test was conducted in the replicates and the growth inhibition was recorded using spectrophotometrically.Based on the results obtained from the experiment the ICG 50 range was from0.102 - 0.130 mg/L.