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Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information
There are no structural alerts that yttrium chromite might has mutagenic potential.
Link to relevant study records
Reference
Endpoint:
genetic toxicity in vitro
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Values are predicted from model. Thus, they provide an approximation compared to experimental measure.
Principles of method if other than guideline:
The following models were applied to examine for structural alerts that indicate the mutagenic potential of yttrium chromite using ChemProp:
Mutagenicity by Kazius et al.
Mutagenicity by Benigni et al.
Micronucleus assay by Benigni et al.
Type of assay:
other: estimated by calculation
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Additional information on results:
Mutagenicity by Kazius et al. (1=active; 0= inactive): 0 - mismatch of chemical domains
Mutagenicity by Benigni et al. (1=active; 0= inactive): 0
Micronucleus assay by Benigni et al. (1=active; 0= inactive): 0
Conclusions:
There are no structural alerts that yttrium chromite might has mutagenic potential.
Executive summary:

We tested for structural alerts that indicate mutagenic potential of yttrium chromite, using ChemProp. For Mutagenicity the models by Kazius et al. and by Benigni et al. were used and additionally we applied the model: Micronucleus assay by Benigni et al. All models indicate that there are no structural alerts that yttrium chromite might has mutagenic potential.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

We tested for structural alerts that indicate mutagenic potential of yttrium chromite, using ChemProp. For Mutagenicity the models by Kazius et al. and by Benigni et al. were used and additionally we applied the model: Micronucleus assay by Benigni et al. All models indicate that there are no structural alerts that yttrium chromite might has mutagenic potential.


Justification for selection of genetic toxicity endpoint
no other data available

Justification for classification or non-classification

There is no indication for mutagenic potential of yttrium chromite, so that the substance is not classified for genetic toxicity.